| Acetaminophen |
1g in 70mL water, 20mL boiling water, 10mL alcohol, 50mL chloroform, 40mL glycerin; slightly soluble in ether. |
|
| Acetazolamide |
Very slightly soluble in cold water; sparingly soluble in hot water; slightly soluble in alcohol. |
Incompatibilities: Acetazolamide Sodium is stated to be physically incompatible with multivitamins. |
| Allopurinol |
Slightly soluble in water or alcohol. |
|
| Amoxicillin |
1g in 370mL water or 2000mL alcohol. |
|
| Ascorbic Acid |
1:3 in water; 1:30 alcohol; 1:50 absolute alcohol; 1:100 glycerin; 1:20 propylene glycol; insoluble in ether, chloroform, benzene, oils, fats, and fat solvents. |
Incompatibilities: Ascorbic acid is a strong monobasic acid that liberates carbon dioxide from carbonates and bicarbonates and forms well‐defined salts with calcium, magnesium, potassium, and sodium. |
| Atenolol |
26.5 mg/mL in water; 300 mg/mL in 1 N HCl; 3 mg/mL in chloroform; freely soluble in methanol; sparing soluble in alcohol. |
|
| Baclofen |
Slightly soluble in water; poorly soluble in organic solvents. |
|
| Betamethasone |
1g soluble in 5300mL water, 65mL alcohol, 325mL chloroform, 3mL methanol at 25°C; 15mL warm alcohol. |
Incompatibilities: Physically incompatible with mupirocin. |
| Betamethasone Acetate |
1g soluble in 2000mL water, 1 in 9 of alcohol, 16mL chloroform; freely soluble in acetone. |
|
| Betamethasone Benzoate |
Insoluble in water; soluble in alcohol, chloroform, and methyl alcohol. |
|
| Betamethasone Diproprionate |
Freely soluble in acetone, chloroform; sparingly soluble in alcohol; insoluble in water. |
|
| Camphor |
It is slightly soluble in water; very soluble in alcohol, chloroform, and ether; freely soluble in carbon disulfide and hexane and in fixed and volatile oils. |
Incompatibilities: A liquid or soft mass is formed when camphor is triturated with chloral hydrate, menthol, phenol, and many other substances. Camphor is readily powdered by triturating with a few drops of alcohol, ether, or chloroform. |
| Captopril |
Freely soluble in water, alcohol, or chloroform. |
|
| Carbamazepine |
Practically insoluble in water; soluble in alcohol, ethanol or acetone; freely soluble in dichloromethane. |
|
| Clonazepam |
Insoluble to practically insoluble in water, slightly soluble in alcohol, acetone; sparingly soluble in chloroform, methanol; slightly soluble in ether, benzene. |
|
| Clonidine HCl |
1g in about 13mL water (20°C), about 25mL alcohol, or about 5000mL chloroform. |
|
| Chlorpheniramine Maleate, USP |
1g in 4mL water, 10mL alcohol, or 10mL chloroform; slightly soluble in ether or benzene. |
|
| Coal Tar |
It is only slightly soluble in water; partially dissolved by alcohol, acetone, methanol, solvent hexane, carbon disulfide, chloroform or ether. |
Alcohol solutions of coal tar or prepared coal tar, prepared with the aid of polysorbate, have been referred to as Liquor Picis Carboni and Liquor Carbonis Detergens. |
| Codeine |
1g in 120mL water, 2mL alcohol, about 0.5mL chloroform, 50mL ether, or about 20mL benzene. When heated in an amount of water insufficient for complete solution, it melts to oily drops that crystallize on cooling. |
Incompatibilities: Precipitated from its aqueous solution by most alkaloidal precipitants but not by sodium, potassium or ammonium carbonate, or sodium bicarbonate. Aqueous solutions are sufficiently alkaline to precipitate other less soluble alkaloids from solutions of their salts. Ammonia may be liberated from ammonium salts. |
| Codeine Phosphate |
1g in 2.5mL water, 325mL alcohol, 0.5mL water at 80°, or 125mL boiling alcohol. |
Being more soluable than codeine sulfate, the phosphate is preferred to the sulfate. See Codeine and Morphine. |
| Codeine Sulfate |
1g in 30mL water, 1300mL alcohol, or approximately 6.5mL water at 80°C; insoluble in chloroform or ether. |
Incompatibilities: See the Alkaloids. It reacts with phenobarbital sodium to produce free alkaloid and phenobarbital, both of which may precipitate, unless the vehicle contains a moderate proportion of alcohol. |
| Dexamethasone |
Practically insoluble in water; sparingly soluble in alcohol, acetone, dioxan, and methyl alcohol; slightly soluble in chloroform; very slightly soluble in ether. |
Incompatibilities: Solutions of dexamethasone combined with isoetharine and terbutaline sulfate form large particulates ( ≥ 10 µm). |
| Dexamethasone Acetate |
Practically insoluble in water; freely soluble in acetone, dioxan, and methyl alcohol. |
|
| Dexamethasone Sodium Phosphate |
1 gram soluble in 2 mL water; slightly soluble in alcohol; very slightly soluble in dioxane; insoluble in chloroform and ether. |
|
| Digoxin |
Practically insoluble in water or ether; slightly soluble in diluted alcohol or chloroform. |
Incompatibilities: None identified. |
| Diltiazem Hydrochloride |
Freely soluble in water, alcohol, or chloroform; soluble in methanol; slightly soluble in dehydrated alcohol |
Incompatibilities: None identified. |
| Dimenhydrinate |
Slightly soluble in water; freely soluble in alcohol or chloroform; sparingly soluble in ether. |
|
| Diphenhydramine HCl |
1g in 1mL water, 2mL alcohol, 2mL chloroform, or 50mL acetone; slightly soluble in benzene or ether. |
Incompatible with solutions of alkalis or strong acids. |
| Ergocalciferol |
Insoluble in water; soluble in organic solvents; slightly soluble in vegetable oils. |
|
| Erythromycin |
1g in approximately 1000mL of water; soluble in alcohol, chloroform, or ether. |
|
| Ferrous Gluconate |
1g in about 5mL water with slight heating; practically insoluble in alcohol. |
Contains 120mg/g of elemental iron. |
| Ferrous Sulfate |
1g in 1.5mL of water or 0.5mL of boiling water; insoluble in alcohol. |
Contains 200mg/g of elemental iron. |
| Folic Acid |
Very slightly soluble in water; insoluble in alcohol, chloroform, or ether; readily dissolves in dilute solutions of alkali hydroxides or carbonates; soluble in hot diluted hydrochloric or sulfuric acid, forming very pale yellow solutions. |
|
| Furosemide |
Practically insoluble in water or dilute acids; freely soluble in methanol, acetone, or solutions of alkali hydroxides (pH>8); sparingly soluble in alcohol; slightly soluble in ether; very slightly soluble in chloroform. |
|
| Glipizide |
Insoluble in water or polar solvents; freely soluble in dimethylformamide or fixed alkalies. |
|
| Guaifenesin |
1g in 60 to 70mL water; soluble in alcohol, chloroform, glycerin, or propylene glycol; insoluble in petroleum ether. |
|
| Guanfacine HCl |
No solubility information available. |
|
| Hydralazine Hydrochloride |
1 g in 25mL water, 500mL alcohol; very soluble in ether. |
|
| Hydrochlorothiazide |
Slightly soluble in water; sparingly soluble in methanol or ethanol; soluble in acetone; freely soluble in sodium hydroxide solution or dimethylformamide; insoluble in ether or chloroform. |
|
| Hydrocodone Bitartrate |
1g in 16mL water; slightly soluble in alcohol; insoluble in ether or chloroform. |
|
| Hydrocortisone |
1g soluble in 40mL alcohol, 80mL acetone; aqueous solubility of about 0.28mg/mL. |
Incompatibilities: Causes degradation of Calcipotriene; separation and layering occurs when combined with Mupirocin. |
| Hydrocortisone Acetate |
In water: 1mg/100mL; in ethanol: 0.45g/100mL; in methanol: 3.9mg/mL; in acetone: 1.1mg/g; in ether: 0.15mg/mL; 1g dissolves in about 200mL chloroform; very soluble in DMF; soluble in dioxane; 1g soluble in 230mL alcohol. |
|
| Hydrocortisone Sodium Succinate |
In water: ≈500mg/mL; similarly soluble in methanol and ethanol; sparingly soluble in chloroform. |
Incompatibilities: Forms haziness and globules with Diazepam; immediate crystal formation with Phenytoin sodium. |
| Hydroxyzine Hydrochloride |
1g in 1mL of water, 4.5mL of alcohol, 13mL of chloroform or 1000mL of ether, very slightly soluble in acetone. |
Incompatibilities: Hydroxyzine Hydrochloride has been reported incompatible with aminophylline, benzylpenicillin salts, chloramphenicol sodium succinate, dimenhydrinate, doxorubicin hydrochloride (in a liposomal formulation), thioridazine, and some soluble barbiturates. |
| Hydroxyzine Pamoate |
1g in 1000mL water, 700mL alcohol, 1000mL chloroform, 1000mL ether, or 10mL dimethylformamide; 1gm in 3.5mL of a 10 N sodium hydroxide solution. |
|
| Ibuprofen |
Slightly soluble in water; soluble in alcohol or other organic solvents. |
|
| Indomethacin |
1g in 50mL alcohol, 30mL chloroform, or 40mL ether; practically insoluble in water. |
|
| Labetalol HCl |
Soluble in water and in alcohol; insoluble in ether and in chloroform. |
Incompatibilities: Sodium bicarbonate. |
| Lamotrigine |
Very slightly soluble in water (0.17mg/ml at 25°C); slightly soluble in 0.1 M HCl (4.1mg/ml at 25°C), methanol, and acetone. |
|
| Lidocaine |
Very soluble in alcohol or chloroform; freely soluble in benzene or ether; practically insoluble in water; dissolves in oils. |
Incompatibilities: Lidocaine forms a eutectic with prilocaine with a melting point less than either ingredient. This eutectic is used in topical formulations. |
| Lidocaine HCl |
It is very soluble in water and in alcohol. |
Incompatibilities: It has been reported to be incompatible in solution with amphotericin B, sulfadiazine sodium, methohexital sodium, cefazolin sodium, or phenytoin sodium. |
| Lindane |
Practically insoluble in water, slightly soluble in ethylene glycol. |
|
| Lisinopril |
1g in 10mL water or 70mL of methanol. |
|
| Menthol |
It is very soluble in alcohol, chloroform, ether, and hexane; freely soluble in glacial acetic acid, mineral oil, and fixed and volatile oils; slightly soluble in water. |
Incompatibilities: The addition of water to alcoholic solutions of menthol causes separation of the menthol. Menthol forms a liquid or soft mass when triturated with a number of substances (e.g., camphor, phenol, thymol, butyl chloral hydrate, chloral hydrate, betanaphthol, resorcinol, and N‐methyl acetanilide). |
| Metoclopramide Hydrochloride |
1g in 0.7mL of water, 3mL of alcohol, and 55mL of chloroform. |
Incompatibilities: May precipitate at pH values > 7.6 that create >1% of the non‐ionized or free base form, B; may form insoluble salts with aromatic organic anions, depending on concentration. |
| Metoprolol Tartrate |
Very soluble in water; freely soluble in methylene chloride, in chloroform, and in alcohol; slightly soluble in acetone; insoluble in ether. |
Incompatibilities: Amphotericin B cholesteryl sulfate complex. |
| Metronidazole |
Sparingly soluble in water, alcohol, or chloroform; slightly soluble in ether. |
|
| Neomycin Sulfate |
1g in approximately 1mL water; readily soluble in 3mL; soluble in methanol and acidified alcohols; very slightly soluble in alcohol; practically insoluble in acetone, chloroform, and ether. |
Incompatibilities: Avoid exposure to heat, light, and moisture; incompatible in solution with some anionic substances, may form a precipitate. |
| Omeprazole, Omeprazole Magnesium |
1g in 8000mL water,and 1g in 25mL alcohol. |
Incompatibilities: Protonation in gastrointestinal contents and subsequent covalent reaction with sulfhydrl groups, ‐SH on proteins, acetylcysteine and cysteine before systemic absorption prevents therapeutic action. |
| Penicillin G Potassium, Sodium |
Very soluble in water; soluble in alcohol (but is inactivated by this solvent), glycerin, or many other alcohols. |
|
| Penicillin V Potassium |
Very soluble in water; 1g in approximately 150mL alcohol. |
|
| Potassium Acetate |
1g in about 0.5mL water or about 3mL alcohol. |
|
| Potassium Bromide |
1g dissolves in 1.5mL water, 250mL alcohol, and 4.6mL glycerin. Preparation US Pat 2989450 (1961). |
|
| Potassium Chloride |
1g in 2.8mL water at 25°C or about 2mL boiling water; insoluble in alcohol. |
|
| Potassium Gluconate |
1g in 3mL water; practically insoluble in dehydrated alcohol, ether, or chloroform. |
|
| Potassium Hydroxide |
It is very soluble in boiling alcohol; freely soluble in water, alcohol, and glycerin. |
|
| Potassium Iodide |
1.4g in 1mL of water at 20°C, 20mg/mL of alcohol, 0.5mg/mL of glycerin, 13.1mg/mL of acetone at 25°C, or 2g/mL of boiling water; when dissolved in water, the reaction is endothermic. 100mL of a saturated aqueous solution at 25°C contains 100g of Kl. |
Incompatibilities: Concurrent use of potassium iodide with lithium and other antithyroid drugs may potentiate the hypothyroid and goitrogenic effects of these medications. Likewise, use with other potassium‐containing medications and potassium‐sparing diurectics may induce hyperkalemia and cardiac arrhythmias or cardiac arrest. |
| Potassium Phosphate, Monobasic |
1g in about 5mL water; insoluble in alcohol. |
|
| Prednisolone |
1g soluble in 30mL alcohol, 180mL chloroform, 50mL acetone. |
|
| Prednisone |
Slightly soluble in alcohol, in chloroform, in dioxane, and in methanol; very slightly soluble in water. |
|
| Progesterone |
Practically insoluble in water; soluble in alcohol, acetone, and dioxan; sparingly soluble in vegetable oils. |
|
| Propranolol Hydrochloride |
About 50mg/mL in water and alcohol; slightly soluble in chloroform; practically insoluble in ether. |
Incompatibilities: Amphotericin B cholesteryl sulfate complex; diazoxide; lansoprazole. |
| Salicylic Acid |
1g in 3mL of both alcohol and ether; soluble in boiling water; sparingly soluble in chloroform; slightly soluble in water and benzene. |
|
| Sodium Acetate |
1g in 0.8mL water or 19mL alcohol. |
|
| Sodium Bicarbonate |
9.6g in 100mL water; insoluble in alcohol. |
Incompatibilities: Many drugs including acids, acidic salts and many alkaloidal salts. |
| Sodium Bromide |
1g dissolves in 1.1mL water, 16mL alcohol, and 6mL methanol. |
Incompatibilities: Soluble bromides present in relatively high concentrations cause alkaloidal precipitants; addition of 20% alcohol prevents the precipitation. Strong oxidizing agents liberate bromine. |
| Sodium Chloride |
1g in 2.8mL water, 10mL glycerin, or 2.7mL boiling water; slightly soluble in alcohol. |
|
| Sodium Nitrite |
1g in 1.5mL water; 0.6 parts boiling water; sparingly soluble in alcohol. |
|
| Spironolactone |
Practically insoluble in water; soluble in alcohol or ethyl acetate; freely soluble in benzene or chloroform; slightly soluble in methanol or fixed oils. |
|
| Terazosin HCl |
Freely soluble in isotonic saline solution; soluble in methanol and in water; slightly soluble in alcohol and in 0.1 N hydrochloric acid; very slightly soluble in chloroform; practically insoluble in acetone and in hexanes. |
|
| Testosterone |
1g soluble in 2mL chloroform, 100mL ether, 6mL absolute alcohol; soluble in ether and other organic solvents; insoluble in water. |
|
| Triamcinolone |
Very slightly soluble in water, chloroform, and ether; slightly soluble in alcohol and menthyl alcohol. |
|
| Urea |
1g in 1mL water, 10mL of 95% alcohol, 20mL anhydrous alcohol, 6mL methanol, or 2mL glycerol; practically insoluble iin chloroform or ether. |
Incompatibilities: Reactive with oxidizing agents; can cause hemolysis in blood, and should not be added to whole blood for transfusion or used in any infusion set used to infuse blood; solutions are unstable and cannot be sterilized by heat; upon standing, heating, or exposure to acids or alkali, hydrolyzed to ammonia and carbon dioxide. |